Throughout the treatment, physiological and biochemical parameters were evaluated. The food restriction (FR) used was 50% of the average daily dietary intake of group C. Then, the 3 groups were subdivided into 6, generating the groups CC (control), CCR (control+food restriction), DEC (diabetic+standard diet), DER (diabetic+food restriction), DNC (diabetic+standard diet) and DNR (diabetic+food restriction), treated for an additional two months (food restriction period). For this, 30 male Wistar rats were distributed in 3 groups (n = 10/group): control (C) diabetes with streptozotocin and cafeteria-style diet (DE) and diabetes with streptozotocin and nicotinamide (DN), all treated for two months (pre-food restriction period). The objective of this study is to evaluate the differences in physiological and biochemical parameters between diabetes models and their responses to food restriction. Food restriction generates benefits, such as reducing oxidative stress, but there are few studies on its effects on diabetes. Abstract There are several animal models of type 2 diabetes mellitus induction but the comparison between models is scarce.
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